A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes
Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineffective. It has been hypothesized that genetically...
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/37933/ |
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| author | Grau-Roma, Llorenc Galindo-Cardiel, I. Isidoro-Ayza, M. Fernández, M. Majó, N. |
| author_facet | Grau-Roma, Llorenc Galindo-Cardiel, I. Isidoro-Ayza, M. Fernández, M. Majó, N. |
| author_sort | Grau-Roma, Llorenc |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineffective. It has been hypothesized that genetically predisposed cats may develop FGESF in response to the introduction of bacteria or other antigens into the intestinal wall. A 9- month-old male Persian cat presented with a history of marked acute haematemesis. A mass (10 cm diameter) was detected within the pylorus and proximal duodenum and this was not surgically accessible. On necropsy examination the duodenal wall was seen to be markedly thickened with extensive mucosal ulceration. Microscopically, there were haphazardly oriented trabecular bands of dense eosinophilic collagen,separated by wide, clear areas containing variable numbers of fibroblasts, eosinophils, mast cells, neutrophils,macrophages, lymphocytes and plasma cells. Numerous pleomorphic, non-parallel walled, sparsely septate hyphae, characteristic of phycomycetes, were present within the collagen matrix. Colonies of gram-positive and gram-negative rods were also present within the lesion. This is the first description of FGESF with intralesional fungi. |
| first_indexed | 2025-11-14T19:34:05Z |
| format | Article |
| id | nottingham-37933 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:05Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-379332020-05-04T16:56:53Z https://eprints.nottingham.ac.uk/37933/ A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes Grau-Roma, Llorenc Galindo-Cardiel, I. Isidoro-Ayza, M. Fernández, M. Majó, N. Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineffective. It has been hypothesized that genetically predisposed cats may develop FGESF in response to the introduction of bacteria or other antigens into the intestinal wall. A 9- month-old male Persian cat presented with a history of marked acute haematemesis. A mass (10 cm diameter) was detected within the pylorus and proximal duodenum and this was not surgically accessible. On necropsy examination the duodenal wall was seen to be markedly thickened with extensive mucosal ulceration. Microscopically, there were haphazardly oriented trabecular bands of dense eosinophilic collagen,separated by wide, clear areas containing variable numbers of fibroblasts, eosinophils, mast cells, neutrophils,macrophages, lymphocytes and plasma cells. Numerous pleomorphic, non-parallel walled, sparsely septate hyphae, characteristic of phycomycetes, were present within the collagen matrix. Colonies of gram-positive and gram-negative rods were also present within the lesion. This is the first description of FGESF with intralesional fungi. Elsevier 2014-11-30 Article PeerReviewed Grau-Roma, Llorenc, Galindo-Cardiel, I., Isidoro-Ayza, M., Fernández, M. and Majó, N. (2014) A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes. Journal of Comparative Pathology, 151 (4). pp. 318-321. ISSN 1532-3129 Cat; Feline gastrointestinal eosinophilic sclerosing fibroplasia; Phycomycetes http://dx.doi.org/10.1016/j.jcpa.2014.08.005 doi:10.1016/j.jcpa.2014.08.005 doi:10.1016/j.jcpa.2014.08.005 |
| spellingShingle | Cat; Feline gastrointestinal eosinophilic sclerosing fibroplasia; Phycomycetes Grau-Roma, Llorenc Galindo-Cardiel, I. Isidoro-Ayza, M. Fernández, M. Majó, N. A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title | A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title_full | A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title_fullStr | A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title_full_unstemmed | A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title_short | A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| title_sort | case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes |
| topic | Cat; Feline gastrointestinal eosinophilic sclerosing fibroplasia; Phycomycetes |
| url | https://eprints.nottingham.ac.uk/37933/ https://eprints.nottingham.ac.uk/37933/ https://eprints.nottingham.ac.uk/37933/ |