A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

Rationale and objectives: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. Methods: The transcriptome from bronchial biopsies and epithelial brushings of 107 moderate-to-s...

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Bibliographic Details
Main Authors: Khuo, Chih-Hsi Scott, Pavlidis, Stelios, Loza, Matthew, Baribaud, Fred, Rowe, Anthony, Pandis, Ioannis, Hoda, Uruj, Rossios, Christos, Sousa, Ana, Wilson, Susan J., Howarth, Peter, Dahlen, Barbro, Dahlen, Sven-Erik, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Sandström, Thomas, De Meulder, Betrand, Lefaudeux, Diane, Fowler, Stephen, Fleming, Louise, Corfield, Julie, Auffray, Charles, Sterk, Peter J., Djukanovic, Ratko, Guo, Yike, Adcock, Ian M., Chung, Kian Fan
Format: Article
Published: American Thoracic Society 2016
Subjects:
severe asthma
bronchial briushing
corticosteroid
insensitivity
T-helper Type 2 (Th2)
Online Access:https://eprints.nottingham.ac.uk/37844/

Internet

https://eprints.nottingham.ac.uk/37844/

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