Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition

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Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS)....

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Bibliographic Details
Main Authors:	Smith, Stuart J., Wilson, Martin, Ward, Jennifer H., Rahman, Cheryl V., Peet, Andrew C., Macarthur, Donald C., Rose, Felicity R.A.J., Grundy, Richard G., Rahman, Ruman
Format:	Article
Published:	Public Library of Science 2012
Online Access:	https://eprints.nottingham.ac.uk/37648/

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