Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition
INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS)....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Public Library of Science
2012
|
| Online Access: | https://eprints.nottingham.ac.uk/37648/ |