Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity

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Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity

Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. Here, we describe key mechanisms in which neuroblas...

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Bibliographic Details
Main Authors:	Mussai, Francis, Egan, Sharon A., Hunter, Stuart, Webber, Hannah, Fisher, Jonathan, Wheat, Rachel, McConville, Carmel, Sbirkov, Yordan, Wheeler, Kate, Bendle, Gavin, Petrie, Kevin, Anderson, John, Chesler, Louis, De Santo, Carmela
Format:	Article
Published:	American Association for Cancer Research 2015
Online Access:	https://eprints.nottingham.ac.uk/37632/

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