Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity
Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. Here, we describe key mechanisms in which neuroblas...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Association for Cancer Research
2015
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| Online Access: | https://eprints.nottingham.ac.uk/37632/ |