New found hope for antibiotic discovery: lipid II inhibitors
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacteria...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Published: |
Wiley
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/37576/ |
| _version_ | 1848795488616185856 |
|---|---|
| author | Ng, Vivian Chan, Weng C. |
| author_facet | Ng, Vivian Chan, Weng C. |
| author_sort | Ng, Vivian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacterial cell components, such as lipid II. This paper provides a summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component. The recent discovery of teixobactin, a new class of lipid II inhibitor has generated substantial research interests. As such, the significant progress that has been achieved towards its development as a promising antibacterial agent is discussed. |
| first_indexed | 2025-11-14T19:32:53Z |
| format | Article |
| id | nottingham-37576 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:32:53Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-375762020-05-04T18:05:41Z https://eprints.nottingham.ac.uk/37576/ New found hope for antibiotic discovery: lipid II inhibitors Ng, Vivian Chan, Weng C. Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacterial cell components, such as lipid II. This paper provides a summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component. The recent discovery of teixobactin, a new class of lipid II inhibitor has generated substantial research interests. As such, the significant progress that has been achieved towards its development as a promising antibacterial agent is discussed. Wiley 2016-08-26 Article PeerReviewed Ng, Vivian and Chan, Weng C. (2016) New found hope for antibiotic discovery: lipid II inhibitors. Chemistry - A European Journal, 22 (36). pp. 12606-12616. ISSN 1521-3765 antibiotics; lipid II inhibitors; macrocyclic peptides; mannopeptimycin; teixobactin http://onlinelibrary.wiley.com/doi/10.1002/chem.201601315/abstract doi:10.1002/chem.201601315 doi:10.1002/chem.201601315 |
| spellingShingle | antibiotics; lipid II inhibitors; macrocyclic peptides; mannopeptimycin; teixobactin Ng, Vivian Chan, Weng C. New found hope for antibiotic discovery: lipid II inhibitors |
| title | New found hope for antibiotic discovery: lipid II inhibitors |
| title_full | New found hope for antibiotic discovery: lipid II inhibitors |
| title_fullStr | New found hope for antibiotic discovery: lipid II inhibitors |
| title_full_unstemmed | New found hope for antibiotic discovery: lipid II inhibitors |
| title_short | New found hope for antibiotic discovery: lipid II inhibitors |
| title_sort | new found hope for antibiotic discovery: lipid ii inhibitors |
| topic | antibiotics; lipid II inhibitors; macrocyclic peptides; mannopeptimycin; teixobactin |
| url | https://eprints.nottingham.ac.uk/37576/ https://eprints.nottingham.ac.uk/37576/ https://eprints.nottingham.ac.uk/37576/ |