Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors

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Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors

A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated Agr...

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Bibliographic Details
Main Authors:	Murray, Ewan J., Crowley, Rebecca C., Truman, Alex, Clarke, Simon R., Cottam, James A., Jadhav, Gopal P., Steele, Victoria R., O’Shea, Paul, Lindholm, Catharina, Cockayne, Alan, Chhabra, Siri Ram, Chan, Weng C., Williams, Paul
Format:	Article
Published:	American Chemical Society 2014
Online Access:	https://eprints.nottingham.ac.uk/37554/

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