Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?
We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereoselective manner to provide taxadiene-4(5)-epoxide (12) as a single diastereoisomer, and that this epoxide can be rearranged to give taxa-4(20),11(12)-dien-5α-ol (4). Furthermore, the epoxide 12 rearranges...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37455/ |