Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia

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Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia

Background: Dysfunction of dopaminergic, GABAergic and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP) and post-weaning social isolation of rats produces a behavioral syndrom...

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Bibliographic Details
Main Authors:	Gaskin, Philip L.R., Toledo-Rodriguez, Maria, Alexander, Stephen P.H., Fone, Kevin C.F.
Format:	Article
Published:	Cambridge University Press 2016
Subjects:	Isolation Rearing Lamotrigine Microarray Phencyclidine Schizophrenia Glutamate
Online Access:	https://eprints.nottingham.ac.uk/37102/

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