Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia
Background: Dysfunction of dopaminergic, GABAergic and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP) and post-weaning social isolation of rats produces a behavioral syndrom...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Cambridge University Press
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/37102/ |