Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation

Eukaryotic translation initiation factor 4E (eIF4E) is considered as the corner stone in the cap-dependent translation initiation machinery. Its role is to recruit mRNA to the ribosome through recognition of the 50 - terminal mRNA cap structure (m7 GpppN, where G is guanosine, N is any nucleotide)....

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Bibliographic Details
Main Authors: Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Poyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E., Fischer, Peter M.
Format: Article
Published: Elsevier 2016
Subjects:
Cancer; eIF4E; protein synthesis; mRNA translation; cap-binding inhibitor
Online Access:https://eprints.nottingham.ac.uk/37084/

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https://eprints.nottingham.ac.uk/37084/

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