The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms...

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Bibliographic Details
Main Authors: Xu, L., Nwosu, Lilian Ngozi, Burston, J.J., Millns, P.J., Sagar, Devi Rani, Mapp, Paul I., Meesawatsom, P., Li, L., Bennett, Andrew J., Walsh, D.A., Chapman, Victoria
Format: Article
Published: Elsevier 2016
Subjects:
Osteoarthritis; pain; bone; inflammation; nerve growth factor
Online Access:https://eprints.nottingham.ac.uk/37071/

Internet

https://eprints.nottingham.ac.uk/37071/

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