Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic formulations

Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic formulations

Lipidic formulations (LFs) are increasingly utilized for the delivery of drugs that belong to class II of the Biopharmaceutics Classification System (BCS). The current work proposes, for the first time, the combination of in vitro lipolysis and microsomal metabolism studies for the quantitative pred...

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Bibliographic Details
Main Authors: Benito-Gallo, Paloma, Marlow, Maria, Zann, Vanessa, Scholes, Peter, Gershkovich, Pavel
Format: Article
Published: American Chemical Society 2016
Subjects:
In vitro lipolysis; microsomal metabolism; IVIVC; oral bioavailability; Δ9-Tetrahydrocannabinol; Cyclosporine A
Online Access:https://eprints.nottingham.ac.uk/36181/

Internet

https://eprints.nottingham.ac.uk/36181/

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