Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions
We report a 12-step catalytic enantioselective formal synthesis of malhamensilipin A (3) and diastereoisomeric analogues from (E)-2-undecenal. The convergent synthesis relied upon iterative epoxidation and phosphorus(V)-mediated deoxydichlorination reactions as well a titanium-mediated epoxide-openi...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35946/ |