Phosphonium polymethacrylates for siRNA delivery: effect of polymer and RNA structural parameters on polyplex assembly and gene knockdown

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Phosphonium polymethacrylates for siRNA delivery: effect of polymer and RNA structural parameters on polyplex assembly and gene knockdown

Synthetic polymers containing quaternary phosphonium salts are an emerging class of materials for the delivery of oligo/polynucleotides. In this work, cationic phosphonium salt-containing polymethacrylates –and their corresponding ammonium analogues– were synthesized by RAFT polymerization. Both the...

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Bibliographic Details
Main Authors:	Loczenski Rose, Vanessa, Shubber, Saif, Sajeesh, S., Spain, Sebastian G., Puri, Sanyogitta, Allen, Stephanie, Lee, Dong-Ki, Winkler, G. Sebastiaan, Mantovani, Giuseppe
Format:	Article
Published:	American Chemical Society 2015
Online Access:	https://eprints.nottingham.ac.uk/35894/

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