Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation

Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and suppressing mitochondrial respiration. In the type 2 diabetic heart, glycolysis is suppressed whereas fatty acid metabolism is promoted. The diabetic heart experiences chronic hypoxia as a consequence of increased obstruc...

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Bibliographic Details
Main Authors: Mansor, Latt S., Mehta, Keshavi, Aksentijevic, Dunja, Carr, Carolyn A., Lund, Trine, Cole, Mark A., Page, Lydia Le, Sousa Fialho, Maria da Luz, Shattock, Michael J., Aasum, Ellen, Clarke, Kieran, Tyler, Damian J., Heather, Lisa C.
Format: Article
Published: Wiley 2016
Online Access:https://eprints.nottingham.ac.uk/35466/

Internet

https://eprints.nottingham.ac.uk/35466/

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