Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

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Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β1-adrenergic (β1AR) receptor monoclonal antibodies (mAbs). The focus of this study was to examine the pharmacology of these antibodies to evaluate thei...

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Bibliographic Details
Main Authors:	Hutchings, Catherine J., Cseke, Gabriella, Osborne, Greg, Woolard, Jeanette, Zhukov, Andrei, Koglin, Markus, Jazayeri, Ali, Pandya-Pathak, Jahnavi, Langmead, Christopher J., Hill, Stephen J., Weir, Malcolm, Marshall, Fiona H.
Format:	Article
Published:	Taylor & Francis 2013
Subjects:	stabilized receptor Beta 1 adrenergic receptor GPCR extracellular domain extracellular loop functional antibody isoprenaline propranolol
Online Access:	https://eprints.nottingham.ac.uk/35274/

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