Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β1-adrenergic (β1AR) receptor monoclonal antibodies (mAbs). The focus of this study was to examine the pharmacology of these antibodies to evaluate thei...

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Bibliographic Details
Main Authors: Hutchings, Catherine J., Cseke, Gabriella, Osborne, Greg, Woolard, Jeanette, Zhukov, Andrei, Koglin, Markus, Jazayeri, Ali, Pandya-Pathak, Jahnavi, Langmead, Christopher J., Hill, Stephen J., Weir, Malcolm, Marshall, Fiona H.
Format: Article
Published: Taylor & Francis 2013
Subjects:
stabilized receptor
Beta 1 adrenergic receptor
GPCR
extracellular domain
extracellular loop
functional antibody
isoprenaline
propranolol
Online Access:https://eprints.nottingham.ac.uk/35274/

Internet

https://eprints.nottingham.ac.uk/35274/

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