Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation

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Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation

At the β1-adrenoceptor, CGP 12177 potently antagonizes agonist responses at the primary high-affinity catecholamine conformation while also exerting agonist effects of its own through a secondary low-affinity conformation. A recent mutagenesis study identified transmembrane region (TM)4 of the β1-ad...

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Bibliographic Details
Main Authors:	Gherbi, Karolina, May, Lauren T., Baker, Jillian G., Briddon, Stephen J., Hill, Stephen J.
Format:	Article
Published:	Federation of American Society of Experimental Biology 2015
Subjects:	dissociation; receptor dimerization; GPCR; allosterism
Online Access:	https://eprints.nottingham.ac.uk/35142/

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