Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation
At the β1-adrenoceptor, CGP 12177 potently antagonizes agonist responses at the primary high-affinity catecholamine conformation while also exerting agonist effects of its own through a secondary low-affinity conformation. A recent mutagenesis study identified transmembrane region (TM)4 of the β1-ad...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Federation of American Society of Experimental Biology
2015
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/35142/ |