Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction
Copper or rhodium catalyzed reaction of diazocarbonyl compounds with β-hydroxyketones gives highly substituted tetrahydrofurans with excellent diastereoselectivity, under mild conditions, in a single step process that starts as a carbene O–H insertion reaction but is diverted by an intramolecular al...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Wiley-VCH Verlag
2015
|
| Online Access: | https://eprints.nottingham.ac.uk/34963/ |
| _version_ | 1848794971957624832 |
|---|---|
| author | Nicolle, Simon M. Lewis, William Hayes, Christopher J. Moody, Christopher J. |
| author_facet | Nicolle, Simon M. Lewis, William Hayes, Christopher J. Moody, Christopher J. |
| author_sort | Nicolle, Simon M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Copper or rhodium catalyzed reaction of diazocarbonyl compounds with β-hydroxyketones gives highly substituted tetrahydrofurans with excellent diastereoselectivity, under mild conditions, in a single step process that starts as a carbene O–H insertion reaction but is diverted by an intramolecular aldol reaction. |
| first_indexed | 2025-11-14T19:24:41Z |
| format | Article |
| id | nottingham-34963 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:24:41Z |
| publishDate | 2015 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-349632020-05-04T17:11:09Z https://eprints.nottingham.ac.uk/34963/ Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction Nicolle, Simon M. Lewis, William Hayes, Christopher J. Moody, Christopher J. Copper or rhodium catalyzed reaction of diazocarbonyl compounds with β-hydroxyketones gives highly substituted tetrahydrofurans with excellent diastereoselectivity, under mild conditions, in a single step process that starts as a carbene O–H insertion reaction but is diverted by an intramolecular aldol reaction. Wiley-VCH Verlag 2015-06-09 Article PeerReviewed Nicolle, Simon M., Lewis, William, Hayes, Christopher J. and Moody, Christopher J. (2015) Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction. Angewandte Chemie International Edition, 54 (29). pp. 8485-8489. ISSN 1521-3773 http://onlinelibrary.wiley.com/doi/10.1002/anie.201502484/abstract doi:10.1002/anie.201502484 doi:10.1002/anie.201502484 |
| spellingShingle | Nicolle, Simon M. Lewis, William Hayes, Christopher J. Moody, Christopher J. Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title | Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title_full | Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title_fullStr | Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title_full_unstemmed | Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title_short | Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction |
| title_sort | stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene o–h insertion reaction |
| url | https://eprints.nottingham.ac.uk/34963/ https://eprints.nottingham.ac.uk/34963/ https://eprints.nottingham.ac.uk/34963/ |