The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism

Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and systemic responses to hypoxia. HIF-pathway manipulation is of therapeutic interest, however global, systemic upregulation of HIF may have as yet unknown effects on multiple processes. We utilized a mouse...

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Bibliographic Details
Main Authors: Slingo, Mary, Cole, Mark, Carr, Carolyn, Curtis, Mary K., Dodd, Michael, Giles, Lucia, Heather, Lisa C., Tyler, Damian, Clarke, Kieran, Robbins, Peter A.
Format: Article
Published: American Physiological Society 2016
Subjects:
Hypoxia-inducible factor
cardiac metabolism
MRI
hyperpolarized pyruvate
Chuvash polycythemia
Online Access:https://eprints.nottingham.ac.uk/34954/

Internet

https://eprints.nottingham.ac.uk/34954/

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