Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis
The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosis in cancer cells but how its pro-apoptotic functi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Impact Journals
2014
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| Online Access: | https://eprints.nottingham.ac.uk/34681/ |