Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models

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Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models

Fragment-based lead discovery (FBLD) holds great promise for drug discovery, but applications to G protein-coupled receptors (GPCRs) have been limited by a lack of sensitive screening techniques and scarce structural information. If virtual screening against homology models of GPCRs could be used to...

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Bibliographic Details
Main Authors:	Ranganathan, Anirudh, Stoddart, Leigh A., Hill, Stephen J., Carlsson, Jens
Format:	Article
Published:	American Chemical Society 2015
Online Access:	https://eprints.nottingham.ac.uk/34664/

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