Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) that selectively antagonizes the FGFR1c isoform [2],...

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Main Authors: Samms, Ricardo J., Lewis, Jo E., Lory, Alex, Fowler, Maxine J., Cooper, Scott, Warner, Amy, Emmerson, Paul, Adams, Andrew C., Luckett, Jeni C., Perkins, Alan C., Wilson, Dana, Barrett, Perry, Tsintzas, Kostas, Ebling, Francis J.P.
Format: Article
Published: Elsevier 2015
Online Access:https://eprints.nottingham.ac.uk/34253/

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https://eprints.nottingham.ac.uk/34253/

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