Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

QR Code

Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective Neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors, and as a lead compound for anti-obesity drugs. Its optically pure...

Full description

Bibliographic Details
Main Authors:	Liu, Mengjie, Mountford, Simon J., Richardson, Rachel R., Groenen, Marleen, Holliday, Nicholas D., Thompson, Philip E.
Format:	Article
Published:	American Chemical Society 2016
Online Access:	https://eprints.nottingham.ac.uk/34144/

Similar Items

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation
by: Haider, Ameena J., et al.
Published: (2011)

Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15
by: Liu, Mengjie, et al.
Published: (2016)

Design and evaluation of fluorescent and non-fluorescent bivalent ligands to explore their mode of action at neuropeptide Y receptors
by: Richardson, Rachel
Published: (2019)

Improved molecular weight control in ring-opening metathesis polymerization (ROMP) reactions with ru-based olefin metathesis catalysts using n. donors and acid: a kinetic and mechanistic investigation
by: Dunbar, M., et al.
Published: (2009)

A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers
by: Kilpatrick, Laura E., et al.
Published: (2015)

Ru-based olefin metathesis catalysts bearing ph-responsive n-heterocyclic carbene (NHC) ligands: Activity control via degree of protonation
by: Balof, S., et al.
Published: (2009)

Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors
by: Kilpatrick, Laura E., et al.
Published: (2012)

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist
by: Stoddart, Leigh A., et al.
Published: (2015)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)

The platelet receptor CLEC-2 is active as a dimer
by: Watson, A., et al.
Published: (2009)

Discovery Of Peroxisome Proliferator-Activated Receptor Gamma Agonist
by: Lee, Guan Sheng
Published: (2013)

Determination of agonist intrinsic efficacies at the dopamine D2 receptor
by: Stott, Lisa Alice
Published: (2017)

Metathesis degradation of natural rubber (NR).
by: Yarmo, Mohd Ambar, et al.
Published: (1988)

Regio- and stereoselective biomimetic synthesis of oligostilbenoid dimers from resveratrol analogues: Influence of the solvent, oxidant, and substitution
by: Ibrahim Ali , Noorbatcha
Published: (2008)

Studies on the biased signalling of some novel delta opioid receptor agonists
by: Asghar, Muhammad Junaid
Published: (2017)

Investigation of Galectin-3 interaction with N. meningitidis and its dimerization with laminin receptor
by: Alqahtani, Fulwah Yahya Saleh
Published: (2012)

Surface immobilisation of antibody on cyclic olefin copolymer for sandwich immunoassay
by: Raj, J., et al.
Published: (2009)

Agonist stimulus trafficking by human prostanoid CRTH2 (DP2) receptors.
by: McArthur Wilson, Richard John
Published: (2007)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)

The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human β1-adrenoceptor
by: Mistry, Shailesh N., et al.
Published: (2016)

Co-metathesis reaction of crude palm oil and ethene
by: Ahmad, F.B.H., et al.
Published: (1995)

The effect of the mu-opioid receptor agonist DAMGO on neonatal rat astrocyte signalling and morphology
by: O'Brien-Cairney, Jack
Published: (2019)

Fluorescent cannabinoids: Stratagies towards the synthesis of fluorescently labelled CB2 receptor ligands
by: Yates, Andrew Stephen
Published: (2005)

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
by: Corriden, Ross, et al.
Published: (2014)

The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors
by: Kilpatrick, Laura E., et al.
Published: (2016)

Chromium(III) based Ziegler-Natta catalysts for olefin polymerization
by: Wong .J.X,, et al.
Published: (2011)

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action
by: Stocks, Michael, et al.
Published: (2014)

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents
by: Cheng, J., et al.
Published: (2015)

Cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists
by: Wragg, Edward
Published: (2023)

Cross metathesis of plant oil: A mini review on reaction condition and catalysis
by: Thangavel, Mythili, et al.
Published: (2020)

Value add palm oil through cross metathesis using 1-octene
by: Thangavel, Mythili, et al.
Published: (2021)

Valorization of palm oil via cross-metathesis reaction using 1-octene
by: M., Thangavel, et al.
Published: (2022)

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor
by: Wall, Richard J., et al.
Published: (2015)

Long receptor residence time of C26 contributes to super agonist activity at the human β2 adrenoceptor
by: Rosethorne, Elizabeth M., et al.
Published: (2016)

Identification of novel peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) agonists using molecular modeling method
by: Kumar, Alan Prem
Published: (2014)

Pengeksploitasian tindak balas metatesis olefin terhadap sumber semulajadi negara.
by: Yarmo, Mohd Ambar, et al.
Published: (1991)

Diterpene chemistry. V* Thallium(III) nitrate oxidations of exocyclic olefins
by: Grant, Peter K., et al.
Published: (1975)

Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009)

Synchronization transition in the double dimer model
by: Wilkins, Neil
Published: (2021)

Agonistic Behaviour in Luxury Branding
by: Sutrisna, Elaine
Published: (2018)