Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective Neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors, and as a lead compound for anti-obesity drugs. Its optically pure...

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Bibliographic Details
Main Authors: Liu, Mengjie, Mountford, Simon J., Richardson, Rachel R., Groenen, Marleen, Holliday, Nicholas D., Thompson, Philip E.
Format: Article
Published: American Chemical Society 2016
Online Access:https://eprints.nottingham.ac.uk/34144/