Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD
Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (p...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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European Respiratory Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/33390/ |
| _version_ | 1848794621408182272 |
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| author | Rabinovich, Roberto A. Miller, Bruce E. Wrobel, Karolina Ranjit, Kareshma Williams, Michelle C. Drost,, Ellen Edwards, Lisa D. Lomas, David A. Rennard, Stephen I. Agustí, Alvar Tal-Singer, Ruth Vestbo, Jørgen Wouters, Emiel F.M. John, Michelle van Beek, Edwin J.R. Murchison, John T. Bolton, Charlotte E. MacNee, William Huang, Jeffrey T.J. |
| author_facet | Rabinovich, Roberto A. Miller, Bruce E. Wrobel, Karolina Ranjit, Kareshma Williams, Michelle C. Drost,, Ellen Edwards, Lisa D. Lomas, David A. Rennard, Stephen I. Agustí, Alvar Tal-Singer, Ruth Vestbo, Jørgen Wouters, Emiel F.M. John, Michelle van Beek, Edwin J.R. Murchison, John T. Bolton, Charlotte E. MacNee, William Huang, Jeffrey T.J. |
| author_sort | Rabinovich, Roberto A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality.
pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic–femoral pulse wave velocity.
pDES was elevated in patients with cardiovascular disease (p<0.005) and correlated with age (rho=0.39, p<0.0005), CACS (rho=0.19, p<0.0005) modified Medical Research Council dyspnoea score (rho=0.15, p<0.0005), 6-min walking distance (rho=−0.17, p<0.0005) and body mass index, airflow obstruction, dyspnoea, exercise capacity index (rho=0.10, p<0.01), but not with emphysema, emphysema progression or forced expiratory volume in 1 s decline. pDES predicted all-cause mortality independently of several confounding factors (p<0.005). In an independent cohort of 186 patients with COPD and 110 control subjects, pDES levels were higher in COPD patients with cardiovascular disease and correlated with arterial stiffness (p<0.05).
In COPD, excess elastin degradation relates to cardiovascular comorbidities, atherosclerosis, arterial stiffness, systemic inflammation and mortality, but not to emphysema or emphysema progression. pDES is a good biomarker of cardiovascular risk and mortality in COPD.Elastin degradation is a hallmark of emphysema and may have a role in the pathogenesis of atherosclerosis with COPD http://ow.ly/Y9GsC |
| first_indexed | 2025-11-14T19:19:06Z |
| format | Article |
| id | nottingham-33390 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:19:06Z |
| publishDate | 2016 |
| publisher | European Respiratory Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-333902020-05-04T17:44:07Z https://eprints.nottingham.ac.uk/33390/ Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD Rabinovich, Roberto A. Miller, Bruce E. Wrobel, Karolina Ranjit, Kareshma Williams, Michelle C. Drost,, Ellen Edwards, Lisa D. Lomas, David A. Rennard, Stephen I. Agustí, Alvar Tal-Singer, Ruth Vestbo, Jørgen Wouters, Emiel F.M. John, Michelle van Beek, Edwin J.R. Murchison, John T. Bolton, Charlotte E. MacNee, William Huang, Jeffrey T.J. Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic–femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (p<0.005) and correlated with age (rho=0.39, p<0.0005), CACS (rho=0.19, p<0.0005) modified Medical Research Council dyspnoea score (rho=0.15, p<0.0005), 6-min walking distance (rho=−0.17, p<0.0005) and body mass index, airflow obstruction, dyspnoea, exercise capacity index (rho=0.10, p<0.01), but not with emphysema, emphysema progression or forced expiratory volume in 1 s decline. pDES predicted all-cause mortality independently of several confounding factors (p<0.005). In an independent cohort of 186 patients with COPD and 110 control subjects, pDES levels were higher in COPD patients with cardiovascular disease and correlated with arterial stiffness (p<0.05). In COPD, excess elastin degradation relates to cardiovascular comorbidities, atherosclerosis, arterial stiffness, systemic inflammation and mortality, but not to emphysema or emphysema progression. pDES is a good biomarker of cardiovascular risk and mortality in COPD.Elastin degradation is a hallmark of emphysema and may have a role in the pathogenesis of atherosclerosis with COPD http://ow.ly/Y9GsC European Respiratory Society 2016-05-01 Article PeerReviewed Rabinovich, Roberto A., Miller, Bruce E., Wrobel, Karolina, Ranjit, Kareshma, Williams, Michelle C., Drost,, Ellen, Edwards, Lisa D., Lomas, David A., Rennard, Stephen I., Agustí, Alvar, Tal-Singer, Ruth, Vestbo, Jørgen, Wouters, Emiel F.M., John, Michelle, van Beek, Edwin J.R., Murchison, John T., Bolton, Charlotte E., MacNee, William and Huang, Jeffrey T.J. (2016) Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. European Respiratory Journal, 47 (5). pp. 1365-1373. ISSN 0903-1936 http://erj.ersjournals.com/content/47/5/1365 doi:10.1183/13993003.01824-2015 doi:10.1183/13993003.01824-2015 |
| spellingShingle | Rabinovich, Roberto A. Miller, Bruce E. Wrobel, Karolina Ranjit, Kareshma Williams, Michelle C. Drost,, Ellen Edwards, Lisa D. Lomas, David A. Rennard, Stephen I. Agustí, Alvar Tal-Singer, Ruth Vestbo, Jørgen Wouters, Emiel F.M. John, Michelle van Beek, Edwin J.R. Murchison, John T. Bolton, Charlotte E. MacNee, William Huang, Jeffrey T.J. Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title | Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title_full | Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title_fullStr | Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title_full_unstemmed | Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title_short | Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD |
| title_sort | circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in copd |
| url | https://eprints.nottingham.ac.uk/33390/ https://eprints.nottingham.ac.uk/33390/ https://eprints.nottingham.ac.uk/33390/ |