Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis
Idiopathic pulmonary fibrosis is a progressive, fatal disease with limited treatment options. Protease-mediated transforming growth factor-β (TGF-β) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in the lung is tightly regulated by protease inhibitors, par...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Publishing Group
2016
|
| Online Access: | https://eprints.nottingham.ac.uk/32862/ |