Design, synthesis and evaluation of MRI ligands for in vivo imaging of protease activity

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Design, synthesis and evaluation of MRI ligands for in vivo imaging of protease activity

This thesis details the design and synthesis of a small library of 19F MRI MMP probes containing an MMP substrate bound to a paramagnetic agent (gadolinium contrast agent) with a fluorine containing group at the opposite terminus. The largest obstacle in the synthesis of the probe was the conjugatio...

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Bibliographic Details
Main Author:	Krupa, James L.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2016
Subjects:	DOTA DO3A AAZTA MRI NMR MMP 19FMRI 19FNMR Contrast agents Gadolinium Europium MRI contrast agent molecular imaging
Online Access:	https://eprints.nottingham.ac.uk/32777/

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