Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom

The influenza pandemic that emerged in 2009 provided an unprecedented opportunity to study adaptation of a virus recently acquired from an animal source during human transmission. In the United Kingdom, the novel virus spread in three temporally distinct waves between 2009 and 2011. Phylogenetic ana...

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Bibliographic Details
Main Authors: Elderfield, Ruth A., Watson, Simon J., Godlee, Alexandra, Adamson, Walt E., Thompson, Catherine I., Dunning, Jake, Fernandez-Alonso, Mirian, Blumenkrantz, Deena, Hussell, Tracy, Zambon, Maria, Openshaw, Peter J.M., Kellam, Paul, Barclay, Wendy S., Nguyen-Van-Tam, Jonathan
Format: Article
Published: American Society for Microbiology 2014
Subjects:
Adaptation
Biological Adolescent Adult Animals Child Child
Preschool Disease Models
Animal Female Genome
Viral Great Britain/epidemiology Humans Infant Infant
Newborn Influenza A Virus
H1N1 Subtype/*genetics/isolation & purification Influenza
Human/epidemiology/*virology Interferons/secretion Lung/immunology/pathology/virology Male Mice
Inbred BALB C *Mutation Orthomyxoviridae Infections/immunology/pathology/virology Phylogeny RNA
Viral Sequence Analysis
DNA Virus Attachment Virus Replication Young Adult
Online Access:https://eprints.nottingham.ac.uk/32743/

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https://eprints.nottingham.ac.uk/32743/

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