Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1) activity and increase airway smooth muscle contraction in asthma

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Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1) activity and increase airway smooth muscle contraction in asthma

Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its relationship with ECM proteins and the resulting fun...

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Bibliographic Details
Main Authors:	Rogers, Natasha K., Clements, Debbie, Dongre, Arundhati, Harrison, Timothy W., Shaw, Dominick E., Johnson, Simon R.
Format:	Article
Published:	Public Library of Science 2014
Online Access:	https://eprints.nottingham.ac.uk/32644/

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