In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011
Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader populations. Objectives: We aimed to assess in-hospita...
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| Format: | Article |
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American Thoracic Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/32623/ |
| _version_ | 1848794451732856832 |
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| author | Hutchinson, John P. Fogarty, Andrew W. McKeever, Tricia M. Hubbard, Richard B. |
| author_facet | Hutchinson, John P. Fogarty, Andrew W. McKeever, Tricia M. Hubbard, Richard B. |
| author_sort | Hutchinson, John P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader populations.
Objectives: We aimed to assess in-hospital mortality following surgical lung biopsy for interstitial lung disease in a national secondary care dataset from the United States.
Methods: Data were obtained from the 2000-2011 Nationwide Inpatient Sample. Cases were identified using International Classification of Diseases (ICD-9-CM) codes for interstitial lung disease and surgical lung biopsies. Lung resections and cases of lung cancer were excluded. Weighted data were used to estimate numbers of biopsies nationwide and in-hospital mortality, and multivariable logistic regression was used to adjust for sex, age, geographic region, co-morbidity, type of operation and provisional diagnosis.
Measurements and Main Results: We estimated there to be around 12,000 surgical lung biopsies performed annually for interstitial lung disease in the United States, two-thirds of which were performed electively. In-hospital mortality was 1.7% for elective procedures, but significantly higher for non-elective procedures (16.0%). Male sex, increasing age, increasing co-morbidity, open surgery and a provisional diagnosis of idiopathic pulmonary fibrosis or connective tissue disease related interstitial lung disease were risk factors for increased mortality.
Conclusions: In-hospital mortality following elective surgical lung biopsy for interstitial lung disease is just under 2%, but significantly higher for non-elective procedures. Identified risk factors for death should be taken into account when counselling patients on whether to pursue a histological diagnosis. |
| first_indexed | 2025-11-14T19:16:24Z |
| format | Article |
| id | nottingham-32623 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:16:24Z |
| publishDate | 2016 |
| publisher | American Thoracic Society |
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| spelling | nottingham-326232020-05-04T17:51:51Z https://eprints.nottingham.ac.uk/32623/ In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 Hutchinson, John P. Fogarty, Andrew W. McKeever, Tricia M. Hubbard, Richard B. Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader populations. Objectives: We aimed to assess in-hospital mortality following surgical lung biopsy for interstitial lung disease in a national secondary care dataset from the United States. Methods: Data were obtained from the 2000-2011 Nationwide Inpatient Sample. Cases were identified using International Classification of Diseases (ICD-9-CM) codes for interstitial lung disease and surgical lung biopsies. Lung resections and cases of lung cancer were excluded. Weighted data were used to estimate numbers of biopsies nationwide and in-hospital mortality, and multivariable logistic regression was used to adjust for sex, age, geographic region, co-morbidity, type of operation and provisional diagnosis. Measurements and Main Results: We estimated there to be around 12,000 surgical lung biopsies performed annually for interstitial lung disease in the United States, two-thirds of which were performed electively. In-hospital mortality was 1.7% for elective procedures, but significantly higher for non-elective procedures (16.0%). Male sex, increasing age, increasing co-morbidity, open surgery and a provisional diagnosis of idiopathic pulmonary fibrosis or connective tissue disease related interstitial lung disease were risk factors for increased mortality. Conclusions: In-hospital mortality following elective surgical lung biopsy for interstitial lung disease is just under 2%, but significantly higher for non-elective procedures. Identified risk factors for death should be taken into account when counselling patients on whether to pursue a histological diagnosis. American Thoracic Society 2016-05-15 Article PeerReviewed Hutchinson, John P., Fogarty, Andrew W., McKeever, Tricia M. and Hubbard, Richard B. (2016) In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. American Journal of Respiratory and Critical Care Medicine, 193 (10). pp. 1161-1167. ISSN 1535-4970 Interstitial lung disease Mortality Surgery http://www.atsjournals.org/doi/10.1164/rccm.201508-1632OC doi:10.1164/rccm.201508-1632OC doi:10.1164/rccm.201508-1632OC |
| spellingShingle | Interstitial lung disease Mortality Surgery Hutchinson, John P. Fogarty, Andrew W. McKeever, Tricia M. Hubbard, Richard B. In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title | In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title_full | In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title_fullStr | In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title_full_unstemmed | In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title_short | In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 |
| title_sort | in-hospital mortality following surgical lung biopsy for interstitial lung disease in the usa: 2000-2011 |
| topic | Interstitial lung disease Mortality Surgery |
| url | https://eprints.nottingham.ac.uk/32623/ https://eprints.nottingham.ac.uk/32623/ https://eprints.nottingham.ac.uk/32623/ |