Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

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Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid  (BQCA). In this study, we explored the structural determ...

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Bibliographic Details
Main Authors:	Mistry, Shailesh N., Lim, Herman, Jörg, Manuela, Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert, Scammells, Peter J.
Format:	Article
Published:	ACS 2016
Online Access:	https://eprints.nottingham.ac.uk/31897/

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