Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor
Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid (BQCA). In this study, we explored the structural determ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
ACS
2016
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| Online Access: | https://eprints.nottingham.ac.uk/31897/ |