RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells

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RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells

Background Telomeric 3’ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt tel...

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Bibliographic Details
Main Authors:	Lagah, Sunil, Tan, I-Li, Radhakrishnan, Priya, Hirst, Robert A., Ward, Jennifer H., O'Callaghan, Chris, Smith, Stuart J., Stevens, Malcolm F.G., Grundy, Richard G., Rahman, Ruman
Format:	Article
Published:	Public Library of Science 2014
Online Access:	https://eprints.nottingham.ac.uk/31762/

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