RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells
Background Telomeric 3’ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt tel...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2014
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| Online Access: | https://eprints.nottingham.ac.uk/31762/ |