Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds
Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities. Hitherto, catalytic formation of versatile p...
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| Format: | Article |
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Wiley-VCH Verlag
2016
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| Online Access: | https://eprints.nottingham.ac.uk/31460/ |
| _version_ | 1848794208725368832 |
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| author | Day, Jonathan McKeever-Abbas, Ben Dowden, James |
| author_facet | Day, Jonathan McKeever-Abbas, Ben Dowden, James |
| author_sort | Day, Jonathan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities. Hitherto, catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; the broad utility demonstrated herein sets the stage for invention of further multicomponent reactions in future. |
| first_indexed | 2025-11-14T19:12:33Z |
| format | Article |
| id | nottingham-31460 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:12:33Z |
| publishDate | 2016 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-314602020-05-04T17:45:09Z https://eprints.nottingham.ac.uk/31460/ Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds Day, Jonathan McKeever-Abbas, Ben Dowden, James Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities. Hitherto, catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; the broad utility demonstrated herein sets the stage for invention of further multicomponent reactions in future. Wiley-VCH Verlag 2016-04-25 Article PeerReviewed Day, Jonathan, McKeever-Abbas, Ben and Dowden, James (2016) Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds. Angewandte Chemie International Edition, 55 (19). pp. 5809-5813. ISSN 1521-3773 carbenes; cycloaddition; diazo compounds; homogenous catalysis; pyridinium ylides http://onlinelibrary.wiley.com/doi/10.1002/anie.201511047/full doi:10.1002/anie.201511047 doi:10.1002/anie.201511047 |
| spellingShingle | carbenes; cycloaddition; diazo compounds; homogenous catalysis; pyridinium ylides Day, Jonathan McKeever-Abbas, Ben Dowden, James Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title | Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title_full | Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title_fullStr | Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title_full_unstemmed | Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title_short | Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| title_sort | stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds |
| topic | carbenes; cycloaddition; diazo compounds; homogenous catalysis; pyridinium ylides |
| url | https://eprints.nottingham.ac.uk/31460/ https://eprints.nottingham.ac.uk/31460/ https://eprints.nottingham.ac.uk/31460/ |