A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis

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A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis

Selective silencing of the cyclooxygenase-2 (COX-2) gene with the loss of the antifibrotic mediator PGE2 contributes to the fibrotic process in idiopathic pulmonary fibrosis (IPF). This study explored the role of G9a- and EZH2-mediated methylation of histone H3 lysine 9 (H3K9me3) and 27 (H3K27me3) i...

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Bibliographic Details
Main Authors:	Coward, William R., Feghali-Bostwick, Carol A., Jenkins, Gisli, Knox, Alan J., Pang, Linhua
Format:	Article
Published:	Federation of American Society of Experimental Biology 2014
Online Access:	https://eprints.nottingham.ac.uk/31459/

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