Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Malaria remains a global health problem, and though international efforts for treatment and eradication have made some headway, the emergence of drug-resistant parasites threatens this progress. Antimalarial therapeutics acting via novel mechanisms are urgently required. P. falciparum M1 and M17 are...

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Bibliographic Details
Main Authors: Drinkwater, Nyssa, Vinh, Natalie B., Mistry, Shailesh N., Bamert, Rebecca S., Ruggeri, Chiara, Holleran, John P., Loganathan, Sasdekumar, Paiardini, Alessandro, Charman, Susan A., Powell, Andrew K., Avery, Vicky M., McGowan, Sheena, Scammells, Peter J.
Format: Article
Published: Elsevier 2016
Subjects:
P. falciparum
Malaria
Aminopeptidase inhibitors
hydroxamic acid
zinc-binding group
Online Access:https://eprints.nottingham.ac.uk/31241/

Internet

https://eprints.nottingham.ac.uk/31241/

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