Natural quinones and their analogues: synthesis, intracellular redox cycling and identification of indoleamine-2,3-dioxygenase (IDO) as a potential target for anticancer activity

QR Code

Natural quinones and their analogues: synthesis, intracellular redox cycling and identification of indoleamine-2,3-dioxygenase (IDO) as a potential target for anticancer activity

Natural quinones, often linked with cellular oxidation processes, also exhibit pronounced biological activity. In particular, the structurally unique isothiazolo-naphthoquinone, aulosirazole, isolated from blue-green alga, possesses selective antitumor cytotoxicity, although its mechanism of action...

Full description

Bibliographic Details
Main Authors:	Blunt, Christopher, Torcuk, Canan, Liu, Yang, Lewis, William, Siegel, David, Ross, David, Moody, Christopher J.
Format:	Article
Published:	Wiley-VCH Verlag 2015
Online Access:	https://eprints.nottingham.ac.uk/30847/

Similar Items

Expression and regulation of the immune modulatory enzyme indoleamine 2,3-dioxygenase (IDO) in human epithelial cells
by: Aldajani, Wejdan/WA
Published: (2016)

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
by: Aldajani, Wejdan A., et al.
Published: (2016)

The role of indoleamine 2,3-dioxygenase in modulating allergic responses
by: Salazar, F.
Published: (2016)

Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase
by: Wana, Mohammed Nasiru, et al.
Published: (2023)

Increased indoleamine 2,3-dioxygenase and quinolinic acid expression in microglia and müller cells of diabetic human and rodent retina
by: Hu, P., et al.
Published: (2017)

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs
by: Salazar, Fabián, et al.
Published: (2017)

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization
by: Salazar, Fabián, et al.
Published: (2016)

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis
by: Nawrat, Christopher C., et al.
Published: (2014)

Redox mediators for thermoelectrochemical cells and electroanalysis of quinones in protic ionic liquids
by: Greatorex-Davies, Peter
Published: (2022)

Tarikan pakaian Vintage Ido
by: Zahrom, Basir
Published: (2014)

Synthesis of oxygen containing heterocycles as potential IDO inhibitors
by: Carvalho, Catarina
Published: (2013)

Exploiting the photochemistry of the quinones
by: Mitchell, Lorna, J.
Published: (2016)

Advances in the synthesis and application of quinones
by: de Freitas Perdigão Dias, Tatiana Alexandra
Published: (2019)

Na+/H+ exchanger 1 (NHE-1) redox-regulated gene and intracellular target for the redox control of cell death sensitivity
by: Akram, S., et al.
Published: (2011)

Structural and mechanistic studies of quinone oxidoreductase II : NQO2
by: Refaey, Rana Hosny
Published: (2011)

Convenient Access to Hydroquinone and Quinone Derivatives from Cyclobutenedione Units
by: Nguyen, Thanh Vinh
Published: (2010)

Mining of ring-hydroxylating dioxygenase genes from PAH contaminated soil metagenome
by: Mohd Ashaari, Mardiana, et al.
Published: (2015)

Expression, purification and characterization of extradiol dioxygenase carbb involved in carbazole degradation pathway
by: Maliki, Intan Mariana, et al.
Published: (2021)

Dioxygenase-encoding AtDAO1 gene controls IAA oxidation and homeostasis in Arabidopsis
by: Porco, Silvana, et al.
Published: (2016)

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90
by: Dutton, Bridie L., et al.
Published: (2014)

Semisynthesis and in vitro anticancer activities of andrographolide analogues
by: Jada, Srinivasa Rao, et al.
Published: (2007)

Hominin home ranges and habitat variability: exploring modern African analogues using remote sensing
by: O'Regan, Hannah J., et al.
Published: (2016)

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects
by: Ji, X., et al.
Published: (2018)

Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra-and intracellular environments
by: Conte, Claudia, et al.
Published: (2018)

Modern and neogene analogues for productive subsurface carbonate systems in SE Asia
by: Madden, Robert Henry Christopher
Published: (2013)

Substrate specificity of angular dioxygenase from carbazole-degrading bacterium Neptuniibacter sp. strain CAR-SF
by: Azizah, Ahmad, et al.
Published: (2015)

On the robustness of entanglement in analogue gravity systems
by: Bruschi, David Edward, et al.
Published: (2013)

Computational evaluation of quinones of Nigella sativa L. as potential inhibitor of dengue virus NS5
by: Roney, Miah, et al.
Published: (2023)

Intracellular delivery of therapeutic antibodies
by: Hackett, Gavin S.
Published: (2012)

Modelling of intracellular calcium dynamics
by: Tilūnaitė, Agnė
Published: (2018)

Anti-angiogenic potential of ardisia crispa roots ethanolic extract and its quinone-rich fraction in mice
by: Awang Hamsin, Dayang Erna Zulaikha
Published: (2013)

Translating intracellular calcium signaling into models
by: Thul, Ruediger
Published: (2014)

A method for purification of intracellular protein.
by: Tey, Beng Ti, et al.
Published: (2009)

Comprehensive insights into the combinatorial uses of selected phytochemicals in colorectal cancer prevention and treatment: isothiocyanates, quinones, carotenoids, and alkaloids
by: Deng, Xi, et al.
Published: (2024)

Redox decoupling and redox budgets: Conceptual tools for thestudy of earth systems
by: Evans, Katy
Published: (2006)

Redox electrolytes in supercapacitors
by: Akinwolemiwa, Bamidele, et al.
Published: (2015)

Frequency of elemental events of intracellular Ca²⁺ dynamics
by: Thul, Ruediger, et al.
Published: (2006)

A method for recovering an intracellular Polyhydroxyalkanoates (PHA).
by: Hassan, Mohd Ali, et al.
Published: (2010)

Isolation of a quinone-rich fraction from Ardisia crispa roots and its attenuating effects on murine skin tumorigenesis
by: Yeong, Looi Ting, et al.
Published: (2013)

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome
by: Atiomo, William, et al.
Published: (2017)