Natural quinones and their analogues: synthesis, intracellular redox cycling and identification of indoleamine-2,3-dioxygenase (IDO) as a potential target for anticancer activity

Natural quinones, often linked with cellular oxidation processes, also exhibit pronounced biological activity. In particular, the structurally unique isothiazolo-naphthoquinone, aulosirazole, isolated from blue-green alga, possesses selective antitumor cytotoxicity, although its mechanism of action...

Full description

Bibliographic Details
Main Authors: Blunt, Christopher, Torcuk, Canan, Liu, Yang, Lewis, William, Siegel, David, Ross, David, Moody, Christopher J.
Format: Article
Published: Wiley-VCH Verlag 2015
Online Access:https://eprints.nottingham.ac.uk/30847/