Genetics of human and canine dilated cardiomyopathy
Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than...
| Main Authors: | , , , , , |
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| Format: | Article |
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Hindawi Publishing Corporation
2015
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| Online Access: | https://eprints.nottingham.ac.uk/30431/ |
| _version_ | 1848793984098369536 |
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| author | Simpson, Siobhan Edwards, Jennifer Ferguson-Mignan, Thomas F.N. Cobb, Malcolm Mongan, Nigel P. Rutland, Catrin S. |
| author_facet | Simpson, Siobhan Edwards, Jennifer Ferguson-Mignan, Thomas F.N. Cobb, Malcolm Mongan, Nigel P. Rutland, Catrin S. |
| author_sort | Simpson, Siobhan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed. |
| first_indexed | 2025-11-14T19:08:58Z |
| format | Article |
| id | nottingham-30431 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:08:58Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-304312020-05-04T17:10:11Z https://eprints.nottingham.ac.uk/30431/ Genetics of human and canine dilated cardiomyopathy Simpson, Siobhan Edwards, Jennifer Ferguson-Mignan, Thomas F.N. Cobb, Malcolm Mongan, Nigel P. Rutland, Catrin S. Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed. Hindawi Publishing Corporation 2015-06-23 Article PeerReviewed Simpson, Siobhan, Edwards, Jennifer, Ferguson-Mignan, Thomas F.N., Cobb, Malcolm, Mongan, Nigel P. and Rutland, Catrin S. (2015) Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015 (204823). pp. 1-13. ISSN 2314-436X cardiovascular disease dilated cardiomyopathy http://www.hindawi.com/journals/ijg/2015/204823/ doi:10.1155/2015/204823 doi:10.1155/2015/204823 |
| spellingShingle | cardiovascular disease dilated cardiomyopathy Simpson, Siobhan Edwards, Jennifer Ferguson-Mignan, Thomas F.N. Cobb, Malcolm Mongan, Nigel P. Rutland, Catrin S. Genetics of human and canine dilated cardiomyopathy |
| title | Genetics of human and canine dilated cardiomyopathy |
| title_full | Genetics of human and canine dilated cardiomyopathy |
| title_fullStr | Genetics of human and canine dilated cardiomyopathy |
| title_full_unstemmed | Genetics of human and canine dilated cardiomyopathy |
| title_short | Genetics of human and canine dilated cardiomyopathy |
| title_sort | genetics of human and canine dilated cardiomyopathy |
| topic | cardiovascular disease dilated cardiomyopathy |
| url | https://eprints.nottingham.ac.uk/30431/ https://eprints.nottingham.ac.uk/30431/ https://eprints.nottingham.ac.uk/30431/ |