Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
Background: BQCA is a selective allosteric modulator of the M1 mAChR.
Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modelling.
Conclusion: BQCA likely occupies a pocket overlapping prototypical mAChR modulators and gains selectivity through coop- erati...
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Bibliographic Details
| Main Authors: |
Abdul-Ridha, Alaa,
López, Laura,
Keov, Peter,
Thal, David M.,
Mistry, Shailesh N.,
Sexton, Patrick M.,
Lane, J. Robert,
Canals, Meritxell,
Christopoulos, Arthur |
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| Format: | Article
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| Published: |
American Society for Biochemistry and Molecular Biology
2014
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| Online Access: | https://eprints.nottingham.ac.uk/30415/
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