Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
Background: BQCA is a selective allosteric modulator of the M1 mAChR. Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modelling. Conclusion: BQCA likely occupies a pocket overlapping prototypical mAChR modulators and gains selectivity through coop- erati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Biochemistry and Molecular Biology
2014
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| Online Access: | https://eprints.nottingham.ac.uk/30415/ |