Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

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Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated by its tendency to induce hypocalcaemia, arising partly from activation of calcium-sensing receptors (CaS receptors) in the thyroid and stimulation of calcitonin release. CaS receptor allosteric modulators that...

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Bibliographic Details
Main Authors:	Cook, A.E., Mistry, Shailesh N., Gregory, K.J., Furness, S.G.B., Sexton, Patrick M., Scammells, Peter J., Conigrave, A.D., Christopoulos, Arthur, Leach, K.
Format:	Article
Published:	Wiley 2014
Online Access:	https://eprints.nottingham.ac.uk/30313/

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