Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

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Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity. Conclusion: Combined analytical, structure-function, and mode...

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Bibliographic Details
Main Authors:	Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Format:	Article
Published:	American Society for Biochemistry and Molecular Biology 2014
Online Access:	https://eprints.nottingham.ac.uk/30312/

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