Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity. Conclusion: Combined analytical, structure-function, and mode...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Biochemistry and Molecular Biology
2014
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| Online Access: | https://eprints.nottingham.ac.uk/30312/ |