Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity. Conclusion: Combined analytical, structure-function, and mode...

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Main Authors: Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Format: Article
Published: American Society for Biochemistry and Molecular Biology 2014
Online Access:https://eprints.nottingham.ac.uk/30312/
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author Abdul-Ridha, Alaa
Lane, J. Robert
Mistry, Shailesh N.
Lopez, Laura
Sexton, Patrick M.
Scammells, Peter J.
Christopoulos, Arthur
Canals, Meritxell
author_facet Abdul-Ridha, Alaa
Lane, J. Robert
Mistry, Shailesh N.
Lopez, Laura
Sexton, Patrick M.
Scammells, Peter J.
Christopoulos, Arthur
Canals, Meritxell
author_sort Abdul-Ridha, Alaa
building Nottingham Research Data Repository
collection Online Access
description Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity. Conclusion: Combined analytical, structure-function, and modeling approaches uncover allosteric mechanisms at the M1 mAChR. Significance: New chemical space can be explored in the development of tailored M1 mAChR PAMs.
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institution University of Nottingham Malaysia Campus
institution_category Local University
last_indexed 2025-11-14T19:08:37Z
publishDate 2014
publisher American Society for Biochemistry and Molecular Biology
recordtype eprints
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spelling nottingham-303122020-05-04T16:55:34Z https://eprints.nottingham.ac.uk/30312/ Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor Abdul-Ridha, Alaa Lane, J. Robert Mistry, Shailesh N. Lopez, Laura Sexton, Patrick M. Scammells, Peter J. Christopoulos, Arthur Canals, Meritxell Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity. Conclusion: Combined analytical, structure-function, and modeling approaches uncover allosteric mechanisms at the M1 mAChR. Significance: New chemical space can be explored in the development of tailored M1 mAChR PAMs. American Society for Biochemistry and Molecular Biology 2014-10-17 Article PeerReviewed Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258 http://www.jbc.org/content/289/48/33701 doi:10.1074/jbc.M114.604967 doi:10.1074/jbc.M114.604967
spellingShingle Abdul-Ridha, Alaa
Lane, J. Robert
Mistry, Shailesh N.
Lopez, Laura
Sexton, Patrick M.
Scammells, Peter J.
Christopoulos, Arthur
Canals, Meritxell
Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title_full Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title_fullStr Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title_full_unstemmed Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title_short Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
title_sort mechanistic insights into allosteric structure-function relationships at the m1 muscarinic acetylcholine receptor
url https://eprints.nottingham.ac.uk/30312/
https://eprints.nottingham.ac.uk/30312/
https://eprints.nottingham.ac.uk/30312/